Preparation of Cyanopyridines by Direct Cyanation

Alan R. Katritzky; Eric F. V. Scriven; Suman Majumder; Hongbin Tu; Anatoliy V. Vakulenko; Novruz G. Akhmedov; Ramiah Murugan

doi:10.1055/s-2005-861849

PAPER

Preparation of Cyanopyridines by Direct Cyanation

Alan R. Katritzky*^a, Eric F. V. Scriven^a, Suman Majumder^a, Hongbin Tu^a, Anatoliy V. Vakulenko^a, Novruz G. Akhmedov^a, Ramiah Murugan^b
^a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
e-Mail: katritzky@chem.ufl.edu;
^b Reilly Industries, Inc, 1500 South Tibbs Avenue, P.O. Box 42912, Indianapolis, IN 46242-0912, USA
e-Mail: rmurugan@reillyind.com ;

Abstract

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Abstract

After pretreatment with nitric acid and trifluoroacetic anhydride, aqueous potassium cyanide converted pyridines 1a-l into their corresponding 2-cyano derivatives 4a-l in an average yield of 52%.

Key words

pyridines cyanation - concd nitric acid - TFAA - potassium cyanide

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References

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